In a Prologue, we see Osiris attacked by Set, and chopped into pieces. Isis, Osiris' wife, searches for him, while Set and his followers unleash chaos on the world. Meanwhile, Bob, a young supermarket bagger, moonlights as a "dog assassin," to rid the world of "alarm clock dogs" and other canines that disturb their suburban neighbors. All is well until he meets Amber; some of her comments cause him to question why he doesn't feel powerful as cannibals do when they devour the blood of their enemies. Worried, he applies to a local mafia Don for a job as a human assassin, and is sent off with two hitman. He is told only to observe, but the trip ends with quite unexpected results, becomes a life-changing event for Bob, and banishing the chaos brought about by Set. In spite of the title, Dog Assassin: The Musical is a tale of spiritual redemption and love.