Eternal Rose is set in 1579 and follows Dante, a man who travels the world for answers pertaining to the disappearance of an old thieves' guild named Blue Rose, which mysteriously vanished over three hundred years ago. Upon rescuing a young orphan woman by the name of Raven, Dante discovers that her mother's locket has the symbol of the blue rose etched into it. Raven, seeking her own answers, makes a deal with Dante. Raven offers to assist him in finding the Blue Rose if he in return helps her find answers to who she really is and where she came from. Dante accepts her offer and the two then begin their journey together for answers.