Pharmacogenomics: Foundations, Competencies, and the Pharmacists' Patient Care Process

Pharmacogenomics: Foundations, Competencies, and the Pharmacists' Patient Care Process provides a basic and clinical foundation for the application of drug-gene interactions in clinical therapeutics. As the field of PGx advances, there is a need for a pharmacy-based, directed resource that can be a reference for practicing pharmacists and student pharmacists. Specific information is presented through "PGx Pearls." Each of the 17 cases are presented in the context of the PPCP, with "Competency Connections" related to genetics and genomics. Each of the 29 chapters providescontent and objective related questions with the answers provided. Two appendices are included. KEY FEATURES: Connects the clinical application with basic foundational principles of pharmacogenomics Includes pharmacogenomics case studies across therapeutic areas PPCP-focused content that reinforces the pharmacists' role in pharmacogenomics Ideal for adoption in courses teaching pharmacogenomics and pharmacogenetics Chapter 1. Foundations of Pharmacogenomics Chapter 2. Pharmacogenomics: Drug Exposure and Response Chapter 3. Pharmacists Competencies in Genetics/Genomics Chapter 4. Information Resources for Pharmacogenomics Chapter 5. Implementation of Pharmacogenomics across Practice Settings Chapter 6. The Pharmacists' Patient Care Process (PPCP) Chapter 7. Cardiology: Clopidogrel/CYP2C19 Case Chapter 8. Cardiology: Simvastatin/SLCO1B1 Case Chapter 9. Cardiology: Warfarin/CYP2C9, VKORC1, CYP4F2 Case Chapter 10. Endocrinology: Glipizide/G6PD Case Chapter 11. Immunology: Tacrolimus/CYP3A5 Case Chapter 12. Infectious Diseases: Abacavir/HLA-B Case Chapter 13. Infectious Diseases: Atazanavir/UGT1A1 Case Chapter 14. Infectious Diseases: Voriconazole/CYP2C19 Case Chapter 15. Neurology: Carbamazepine/HLA-A, HLA-B Case Chapter 16. Neurology: Phenytoin/CYP2C9, HLA-B Case Chapter 17. Oncology: Somatic Disease and Pharmacogenomics Chapter 18. Oncology: Mercaptopurine/TPMT Case Chapter 19. Oncology: Fluorouracil/DPYD Case Chapter 20. Oncology: Rasburicase/G6PD Case Chapter 21. Psychiatry: Amitriptyline/CYP2C19, CYP2D6 Case Chapter 22. Psychiatry: Paroxetine/CYP2D6 Case Chapter 23. Respiratory: Ivacaftor/CFTR Case Chapter 24. Rheumatology/Musculoskeletal Pain: Allopurinol/HLA-B Case Chapter 25. Rheumatology/Musculoskeletal Pain: Azathioprine/TPMT, Celecoxib/CYP2C9 Case Chapter 26. Rheumatology/Musculoskeletal Pain: Codeine/CYP2D6 Case Chapter 27. Pharmacogenomics Testing Chapter 28. Pharmacogenomics in Ethical and Social Contexts Chapter 29. Pharmacogenomics and Secondary/ Incidental Findings Appendix 1: Competency Connections Appendix 2: Glossary

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