Artificial Intelligence Applications in Human Pathology

Artificial Intelligence Applications in Human Pathology deals with the latest topics in biomedical research and clinical cancer diagnostics. With chapters provided by true international experts in the field, this book gives real examples of the implementation of AI and machine learning in human pathology.

Advances in machine learning and AI in general have propelled computational and general pathology research. Today, computer systems approach the diagnostic levels achieved by humans for certain well-defined tasks in pathology. At the same time, pathologists are faced with an increased workload both quantitatively (numbers of cases) and qualitatively (the amount of work per case, with increasing treatment options and the type of data delivered by pathologists also expected to become more fine-grained). AI will support and leverage mathematical tools and implement data-driven methods as a center for data interpretation in modern tissue diagnosis and pathology. Digital or computational pathology will also foster the training of future computational pathologists, those with both pathology and non-pathology backgrounds, who will eventually decide that AI-based pathology will serve as an indispensable hub for data-related research in a global health care system.

Some of the specific topics explored within include an introduction to DL as applied to Pathology, Standardized Tissue Sampling for Automated Analysis, integrating Computational Pathology into Histopathology workflows. Readers will also find examples of specific techniques applied to specific diseases that will aid their research and treatments including but not limited to; Tissue Cartography for Colorectal Cancer, Ki-67 Measurements in Breast Cancer, and Light-Sheet Microscopy as applied to Virtual Histology.

The key role for pathologists in tissue diagnostics will prevail and even expand through interdisciplinary work and the intuitive use of an advanced and interoperating (AI-supported) pathology workflow delivering novel and complex features that will serve the understanding of individual diseases and of course the patient.

Contents:

• Foreword
• About the Editors
• Introduction: Integration of Computational Pathology and AI Application into Histopathology Workflow (Ralf Huss)
• Standardized Tissue Sampling for Automated Analysis and Global Trial Success (Eike von Leitner, Philipp Layer, and Hartmut Juhl)
• Light-Sheet Microscopy as a Novel Tool for Virtual Histology (René Hägerling and Fabian Mohr)
• Stain Quality Management and Biomarker Analysis (Søren Nielson)
• Measuring Ki-67 in Breast Cancer: Past, Present, and Future (Andrew Dodson)
• Multiplex: From Acquisition to Analysis (Regan Baird and David Mason)
• An Introduction to Deep Learning in Pathology (Jeremias Krause, Heike I Grabsch, and Jakob Nikolas Kather)
• AI-Driven Precision Pathology: Challenges and Innovations in Tissue Biomarker Analysis for Diagnosis (Dirk Vossen, Jeppe Thagaard, Fabian Schneider, Rasmus Norré Sørensen, Johan Doré, Esther Abels, Amanda Lowe, Mogens Vyberg, and Michael Grunkin)
• Tissue Cartography for Colorectal Cancer (Volker Bruns, Michaela Benz, and Carol Geppert)
• Graph Representation Learning and Explainability in Breast Cancer Pathology: Bridging the Gap between AI and Pathology Practice (Pushpak Pati, Guillaume Jaume, Antonio Foncubierta-Rodriguez, Florinda Feroce, Giosue Scognamiglio, Anna Maria Anniciello, Nadia Brancati, Maria Frucci, Daniel Riccio, Jean-Philippe Thiran, Orcun Goksel, and Maria Gabrani)
• AI-Driven Design of Disease Sensors: Theoretical Foundations (Simone Bianco, Sara Capponi, and Shangying Wang)
• Index

Readership: Advanced graduate and undergraduate students in the field of life

Dettagli