In Pup-Squeak town of New Dog City, a playful Chocolate Lab, Callie Poodle Lab
lives next to the bossy neighbor, Prudence PussyClaws, who happens to be from South Catolina, a cat of course. Callie's twin brother, Henry, (he has the brown spot on the opposite eye of Callie), loves fetch, and is on the basketball team. Darwin is her oldest second cousin, Caroline is her sister, and Billy is her youngest brother. Callie and Henry always prank Prudence with Madam Salmon kitten chow with help from Callie's friends. Callie and Henry are in 4th grade at Dogwood Elementary school.