Chronic kidney disease (CKD) is a progressive loss of kidney function over time. The kidneys play a crucial role in filtering waste products and excess fluids from the bloodstream, and when they are not functioning properly, waste can build up in the body and cause damage to other organs. There are many causes of CKD, including diabetes, high blood pressure, and genetic disorders. Symptoms of CKD may include fatigue, poor appetite, swelling of the ankles and feet, and trouble sleeping. If left untreated, CKD can lead to end-stage kidney failure, which requires dialysis or a kidney transplant to maintain life. The management of CKD typically involves controlling underlying conditions such as hypertension, glucose intolerance, and hyperlipidemia, slowing the progression of the disease by healthy lifestyle choices, and regular monitoring of kidney function through blood and urine tests.