Aimed primarily at operating organizations of nuclear power plants (NPPs) and regulatory bodies, this Safety Guide provides specific recommendations to ensure that operations in NPPs are conducted in a safe, effective, thorough and professional manner. It identifies the main responsibilities and operating practices in relation to such safe operation. The structure of the operations department, which is the part of the operating organization responsible for the conduct of operations of an NPP is addressed. Also addressed are the setting of high standards of performance and making safety related decisions in an effective manner, conducting control room activities in a thorough and professional manner and maintaining a nuclear power plant within the established operational limits and conditions.