Current Progress of Mitochondrial Transplantation: A new paradigm of therapeutic intervention promoting Neuronal Re-generation for Neurodegenerative Diseases, Stroke, & CNS injury. An Overview

Neuronal Re-generation for Neurodegenerative Diseases, Stroke, & CNS injury. An Overview.

Mitochondria are the major source of intracellular adenosine triphosphate (ATP) and play an essential role in a plethora of physiological functions, including the regulation of metabolism and the maintenance of cellular homeostasis.

Mutations of mitochondrial DNA, proteins and impaired mitochondrial function have been implicated in the neurodegenerative diseases, stroke and injury of the central nervous system (CNS).

The dynamic feature of mitochondrial fusion, fission, trafficking and turnover have also been documented in these diseases.

A major bottleneck of traditional approach to correct mitochondria-related disorders is the difficulty of drugs or gene targeting agents to arrive at specific sub-compartments of mitochondria.

Moreover, the diverse nature of mitochondrial mutations among patients makes it impossible to develop one drug for one disease.

To this end, mitochondrial transplantation presents a new paradigm of therapeutic intervention that benefits neuronal survival and regeneration for;

Neurodegenerative diseases,
Stroke, and
CNS injury.

Supplement of healthy mitochondria to damaged neurons has been reported to promote neuronal viability, activity and neurite re-growth.

Thus an attempt has been made in this Booklet to provide an overview of the recent advance and development on emerging mitochondrial therapy.

Dr. H. K. Saboowala.

M.B.(Bom) .M.R.S.H.(London)

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