Five years after her sister disappeared, seventeen-year-old Adrienne finds the strength to return to her father's home in New Orleans. But soon after she arrives, the mark of a curse appears on her, leaving her worried. Will she be the next victim of a four-hundred-year old family curse ... the next to be claimed by a serial killer roaming the back alleys of the city?
The day before his senior year begins, Jayden is given a skeleton key passed down through his family for generations -- a gruesome reminder of how his ancestors betrayed their own people and sold them into slavery. He doesn't believe in the curse the key allegedly bears and puts it away with the intention of forgetting about its message. Until he meets Adrienne, a girl he's compelled to for more reasons than her beauty.
He's not the only one who notices her. A man in a skeleton mask and a voodoo gang member are also drawn to Adrienne. One is determined to protect her. The other intends to mislead her. Haunted by the mythical Red Man, all are connected to the ancient curse.
Can they overcome their misgivings about one another and prevent the dark prophecy looming over them? Or will they be lured away from each other by evil's siren song?