A Glance at Currently Accepted "Hallmarks of glycosylation in cancer & Future Perspectives".

A Glance at Currently Accepted "Hallmarks of glycosylation in cancer & Future Perspectives".

The hallmarks of cancer were originally outlined in 2000 and comprised six biological capabilities acquired during the multi-step development of cancer that allow cancer cells to:

Survive,
pProliferate and
Disseminate.

Aberrant glycosylation in cancer was first described more than 45 years ago, and since then it has been well documented that fundamental changes in the glycosylation patterns of cell surface and secreted glycoproteins occur during malignant transformation and cancer progression.

Glycans have roles in cancer cell signalling, tumour cell dissociation and invasion, cell-matrix interactions, angiogenesis, metastasis and immune modulation.

Aberrant glycosylation is often cited as a 'hallmark of cancer' but is notably absent from both the original hallmarks of cancer and from the next generation of emerging hallmarks.

Thus, it is strived here in this Booklet to discuss how glycosylation is clearly an enabling characteristic that is causally associated with the acquisition of all the hallmark capabilities and Future Perspectives.

Dr. H. K. Saboowala.

M.B.(Bom) .M.R.S.H.(London)

Dettagli