Huntington's disease (HD) is one of the most common dominantly inherited neurodegenerative disorders, characterized by a clinical trial of movement disorder, cognitive deficits, and psychiatric symptoms. Huntington's Disease: Pathogenic Mechanisms and Implications for Therapeutics, reviews the most up-do-date content on HD pathogenic mechanisms and cutting-edge testing of therapeutic strategies for HD. Chapters explore areas such as, normal huntingtin biology in brain development and function, genetic modifiers of HD in patients, molecular pathogenic mechanism in HD, and mechanisms underlying selective neuronal vulnerability
Reviews the clinical course and genetics of HD
Reviews the biology of human huntingtin and HD-relevant cell types
Reviews the wide range of pathobiology associated with mutant huntingtin
Reviews genetic studies of HD and how these studies are informing the development of new therapeutic approaches
Reviews new tools and model systems for basic and translational research in HD, including new human-derived model systems, as well as systems biology and artificial intelligencedriven approaches
Provides an overview of new therapeutic approaches and current clinical programs in HD