Neither database nor framework should shape your application. Business needs should. Unfortunately, it might have got out of sight due to years spent on writing Django- or Rails-like web applications with Active Record ORMs.
The Clean Architecture is an approach that puts your customer's concerns in the centre of software. All other issues, such as persistence are treated as implementation details. This is achieved thanks to a careful layering of the project.
As a result, business rules are decoupled from frameworks and 3rd party services. Therefore you can rapidly prototype and test core value. Everything has its place, which makes i.e. onboarding new team members a breeze. Last, but certainly not least as time passes and project grows the Clean Architecture lets you maintain order and remain flexible.