Left Hand of the Moon is an American Romeo and Juliet story about doomed love between the very young. In the early 1800s, as the fledgling United States completes the Louisiana Purchase and marches troops through the newly acquired state, executing by firing squad the freed adult children of enslaved women and their owners, an enslaved teen and her owner's youngest son run away to live together. They have grown up together and have always trusted and loved each other. Now that adulthood threatens to force them into roles they would rather die than play, the passionate young couple determines to create their own future.