The Leukemia-Lymphoma Cell Line Factsbook represents an essential reference manual for all of the well-characterized leukemia-lymphoma cell lines currently available. It provides the most important facts, using the succinct and user-friendly format that has made the FactsBooks so popular with scientists and clinical researchers. Introductory chapters provide background and perspective for culturing malignant hematopoietic (blood forming) cell lines. These chapters are followed by over 400 comprehensive individual entries. Each cell line entry highlights essential clinical, immunological, genetic, and functional features and includes a comprehensive listing of references.
The full spectrum of malignant cell lines from all hematopoietic cell lineages
Sister cell lines and relevant subclones
Clinical data: patient, diagnosis, treatment status, and specimen source
Authentication of derivation and availability
Immunophenotype
Cytogenetic karyotype
Translocations and fusion genes
Receptor gene rearrangements and genetic alterations
Cell cultures aspects: establishment, medium, doubling time, growth
Cytochemical profile
Cytokine production and response to cytokines
Proto-oncogene and transcription factor expression/alteration