When investment banker Lazzaro de Medici is found dead, Professor of Biblical Studies at University of Illinois at Chicago Aiden Leonardo is the prime suspect. In possession of an encrypted letter given to him by Lazzaro, Aiden utilizes his extensive knowledge of Scripture to piece together clues that lead to a Lost Bible dating back to the time of Christ.
Things are further complicated when a mysterious stranger warns Aiden that possessing the secret of heaven could cost him his life. Pursued by the F.B.I. for the ancient Black market relic and the Chicago PD in connection to the murder of Lazzaro de Medici, Aiden races against the clock to prove his innocence and fulfill his mentor's dying wish.