Skye Fargo's making his way back east to St. Louis when he comes across a horrible sight on the Nebraska prairiea burning cabin, and an entire family shot execution-style and laid out. He soon learns that there's a killer on the loosesmallpox. But there's someone out there worse than the disease. They're called night riders, and they're out to make sure that anyone with smallpoxand those near themdon't live long enough to spread the illness. Now, the Trailsman is going to give the cowardly killers a dose of their own medicine