Vampires vs Zombies follows a global pandemic thought to be restricted to the world of fiction as it takes out nearly the entire population within the span of a few days. The survivors are confused and disoriented. Those who die don't stay dead.
Aurora Mathews along with Damian Deshea, a man who aggravates her more than the walking deadsomehow manages to survive the first onslaught of violence and destruction only to be taken captive by something possibly more terrifying than zombies vampires.
Each passing night reveals new horrors to the duo. Most alarming of all is the presence of Kieran, a vampire whose newest goal in his afterlife is to see Aurora dead.
Kieran has a history of violence, and women tend to disappear once he takes an interest in them, and he sees Aurora as his last chance of showing off his skills. To top it off, Damian is hiding secrets nearly as dark as those kept by their captors.
Between looking for other survivors, desperately searching for her family, and fighting off attempts on her life, Aurora must learn to adapt to this new world or perish. This is the battle of human survival that she fears can only end in death.