This book constitutes the thoroughly refereed proceedings of the 6th International Conference on e-Infrastructure and e-Services for Developing Countries, AFRICOMM 2014, held in Kampala, Uganda, November 24-25, 2014. The 31 revised full papers were carefully selected from 57 submissions and cover topics such as communication infrastructure, health, IoT, cloud computing and TVWS, ICT4D applications, access to information, and ICT4D miscellaneous.