In the wake of the massacre at Moon Lake Park Alice is reeling from grief, and the deaths of the majority of the weredog council has led to the formation of a new ruling body made up of members who want to actively hunt for the remaining packs and get revenge for their losses. Ignoring Alice's advice, they send out scouts intent on hunting down the remaining fugitive wolves.
But a more dire threat makes these problems pale in comparison, a disease carried by Alice's wolf that's growing stronger with every transformation. The FBI's attempts at treatment only make matters worse, and if a cure isn't found soon, the next shift could kill Alice's wolf, and her along with it.